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2021-03-30 - Colloque/Présentation - poster - Anglais - page(s)

Delpierre Antoine , Akan Melisa, Deroux Chloé, Jenart Vincianne , Ris Laurence , Decleves Anne-Emilie , Legrand Alexandre , Villers Agnès , Tassin Alexandra , "Effect of voluntary and forced exercise on FNDC5-Irisin pathway and muscle-to-brain crosstalk in a model of obesity" in Mardi des chercheurs , Valenciennes, France, 2021

  • Codes CREF : Physiologie générale (DI3220)
  • Unités de recherche UMONS : Physiologie et réadaptation respiratoire (M117), Neurosciences (M119), Biochimie métabolique et moléculaire (M122)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) Effect of voluntary and forced exercise on FNDC5-Irisin pathway and muscle-to-brain crosstalk in a model of obesity. A. Delpierre, M. Akan, V. Jenart, C. Deroux, L. Ris, A-E. Declèves, A. Legrand, A.Villers and A. Tassin Exercise training (ET) has a positive effect on brain health. Although molecular mechanisms are poorly understood, a cross-talk between skeletal muscle and brain has been described. Irisin, an exerkine, is linked to neurotrophic factors like BDNF. This relation is an argument to consider Irisin as a messenger between muscle and brain. However, the contribution of muscle-derived Irisin on cognitive function remains controversial, as the influence of obesity or ET modalities (spontaneous or endurance). Our goal is to determine (1) inter-relationships between FNDC5/Irisin pathway and cognition in function of ET modalities and (2) whether muscle-to-brain crosstalk is altered in the context of obesity.