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2021-01-22 - Colloque/Présentation - poster - Anglais - page(s)

Remson Alexandre , Gabriele Sylvain , Surin Mathieu , "Poster GDR 2021" in GDR AQV 2021 : Approche quantitative du vivant, Online, France, 2021

  • Codes CREF : Chimie macromoléculaire (DI1315), Biologie cellulaire (DI311D)
  • Unités de recherche UMONS : Chimie des matériaux nouveaux (S817), Laboratoire Interfaces et Fluides complexes (S885)
  • Instituts UMONS : Institut de Recherche en Science et Ingénierie des Matériaux (Matériaux), Institut des Biosciences (Biosciences)
  • Centres UMONS : Centre d’Innovation et de Recherche en Matériaux Polymères (CIRMAP)
Texte intégral :

Abstract(s) :

(Anglais) Chirality is ubiquitous in Nature, from living organisms to biomolecules, and influences fundamental processes that involve intermolecular interactions. Interestingly, many of these biological processes are based on cell proliferation and migration, that both take place in interaction with proteins of the extracellular matrix (ECM). While various physico-chemical cues of the cell microenvironment have been studied extensively, the influence of the ECM chirality on the cellular migration has been overlooked. To explore this issue, we propose to use multi-hierarchical self-assembly of (oligo)peptides to design well-defined in vitro migration assays. By using this multidisciplinary approach, we will investigate the effect of chirality, from the molecular to the supramolecular level, on the migration of epithelial cells in 2D and 3D microenvironments. We aim at understanding how molecular and supramolecular chirality can modulate integrin-based mechanotransduction mechanisms involved in cell migration.