Abstract(s) :

(Anglais) Biosensing is an ever-growing multidisciplinary field of research, giving the floor to more and more innovations over the years to address the increasing needs of our society for affordable, fast and reliable Point-of-Care (POC) home-diagnoses. This thesis has aimed to investigate new strategies to improve performance of cancer biomarkers biosensing by using Tilted fiber Bragg Gratings (TFBGs). This component photo-inscribed in the core of an optical fiber leads to highly sensitive biosensors once biofunctionalized and coupled to the surface plasmon resonance (SPR). The SPR occurs by covering the grating surface with a nanometer-scale gold film. Several types of optical fibers and new demodulation techniques have been tested to optimize the response analysis and the response analysis and the practicability of the probe.The original electro-plasmonic technique based on the electrophoresis principle has also been designed to directly attract biological targets onto the optical fiber and greatly enhance the limit of detection. Promising results have also been obtained in breast cancer cells biodetection. This thesis allows to better glimpse the application of SPR-TFBGs as a lab-on-chip technology to support in situ diagnoses in a more convenient way.