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2010-08-01 - Article/Dans un journal avec peer-review - Anglais - 9 page(s)

Suriano Fabian, Coulembier Olivier , Dubois Philippe , "Synthesis of amphiphilic A3B mikto-arm copolymer from a sugar core : combination of hydrophobic PCL and hydrophilici glycopolymers for biocompatible nanovector preparation" in Journal of Polymer Science. Part A-1, Polymer Chemistry, 48, 15, 3271-3280

  • Edition : Interscience Publishers (United Kingdom)
  • Codes CREF : Chimie macromoléculaire (DI1315), Catalyses hétérogène et homogène (DI1334)
  • Unités de recherche UMONS : Matériaux Polymères et Composites (S816)
  • Instituts UMONS : Institut de Recherche en Science et Ingénierie des Matériaux (Matériaux)
Texte intégral :

Abstract(s) :

(Anglais) Amphiphilic A3B mikto-arm copolymers have been synthesized using a t-butyl-diphenyl silyl-based methylglucoside derivative. The latter has been first used as initiator for the polymerization of e-caprolactone leading to three-arm star-shaped structures followed by several postpolymerization steps to obtain star-shaped poly(e-caprolactone) macroinitiator. Atom transfer radical polymerization (ATRP) of diisopropylidene galactose methacrylate in THF at 60 °C using CuBr ligated with 1,1,4,7,10,10-hexamethyltriethylenetetramine (HMTETA) as catalytic complex allowed the formation of A3B mikto-arm copolymers with different compositions and molecular weights. Selective deprotection of sugar protecting groups finally generated amphiphilic mikto-arm copolymers. The molecular characterization of those copolymers was performed by 1H NMR spectroscopy and gel permeation chromatography (GPC) analysis. The self-assembly of the copolymers into micellar aggregates and the related critical micellization concentration (CMC) in aqueous media were determined by dynamic light scattering (DLS) and UV-visible spectroscopy, respectively

Notes :
  • (Anglais) publiée en ligne le 25 juin 2010
Identifiants :
  • DOI : 10.1002/pola.24109