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2016-07-08 - Colloque/Présentation - poster - Anglais - 1 page(s)

Callewaert M., Rigaux G, Belabassi Yamina, cadiou C, Moreau Juliette, Ewald M, Molinari M., Portefaix C., Henoumont Céline , Laurent Sophie , Vander Elst Luce , Muller Robert , Bauduin B, Boutry Sébastien , Gheran V, Petrache Voicu SN, Dinischiotu Anca, Chuburu F., "Biocompatible nanohydrogels incorporating conventional MRI contrast agents : simple design, huge performances" in ICCC, 42nd International Conference on coordination chemistry, Brest, France, 2016

  • Codes CREF : Physico-chimie générale (DI1320), Chimie des colloïdes (DI1329)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé), Institut des Biosciences (Biosciences)
  • Centres UMONS : Centre de Recherche en Microscopie et Imagerie Médicale (CMMI)

Abstract(s) :

(Anglais) Due to its high anatomical resolution, magnetic resonance imaging (MRI) is one of the most powerful non-invasive techniques for clinical diagnosis. However, information obtained from a simple unenhanced MR image is often not sufficient to highlight the areas of interest. Then, the contrast has to be improved by administering paramagnetic contrast-enhancing agents, mainly gadolinium chelates (GdCAs). Nevertheless at medical fields, their contrast enhancing capacity (quantitatively represented as relaxivity ri) is low. To circumvent this important limitation, our objective is to tune the sensitivity of commercially available GdCAs into hypersensitive MRI probes. On the basis of SBM theory1, we have developed a series of biocompatible polysaccharide-based nanohydrogels for the encapsulation of GdCAs (GdCANPs) 2. These nanohydrogels elaborated by an easy and robust ionotropic gelation process3, encapsulate various GdCAs4 in a highly hydrated nanostructure. In the presentation, we will demonstrate that according to the nature of the polymer matrix, r1 relaxivities per Gd centre as high as 100 s-1 mM-1 at 30 MHz can be reached. The NMRD profiles will confirm that GdCA molecular motions are restricted and water access to the inner core of these nanogels not limited. T1- and T2-weighted images recorded at 3 T will show that this relaxation enhancement is clearly translated into a magnified contrast, demonstrating the powerful dual mode imaging ability of such nanosytems. Finally, cytotoxicity studies will demonstrate GdCANPs safety and their use for lymph node imaging will be addressed. 1 A. E. Merbach, L. Helm and E. Toth, The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, Wiley, Chichester, 2013, 2nd edition. 2 T. Courant, V. G. Roullin, C. Cadiou, M. Callewaert, M. C. Andry, C. Portefaix, C. Hoeffel, M. C. de Goltstein, M. Port, S. Laurent, L. Vander Elst, R. N. Muller, M. Molinari, F. Chuburu, Angew. Chem. Int. Ed. 2012, 51, 9119. 3 F. A. Oyarzun-Ampuero, J. Brea, M. I. Loza, D. Torres, M. J. Alonso, Int. J. Pharm. 2009, 381, 122. 4 M. Callewaert, V. G. Roullin, C. Cadiou, E. Millart, L.Van Gulik, M. C. Andry, C. Portefaix, C. Hoeffel, S. Laurent, L. Vander Elst, R. Muller, M. Molinari, F. Chuburu, J. Mater. Chem. B, 2014, 2, 6397.