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2004-08-01 - Article/Dans un journal avec peer-review - Anglais - 4 page(s)

Mayence A., Vanden Eynde Jean-Jacques , Huang T.L., "Evidences for the Formation of Bisbenzamidines-heme Complexes in Cell-free Systems" in Bioorganic & Medicinal Chemistry Letters, 14, 7, 1625 -1628

  • Edition : Elsevier Science, Oxford (United Kingdom)
  • Codes CREF : Chimie organique (DI1313)
  • Unités de recherche UMONS : Chimie organique (S836)
Texte intégral :

Abstract(s) :

(Anglais) Infrared and colorimetry data suggest that bisbenzamidines connected by various rigid or flexible linkers are able to interact with heme in cell-free systems. At pH 5.0 the inhibition of formation of ß-hematin could be ascertained by infrared spectroscopy whereas at pH 7.0 the interaction yielded insoluble complexes for which a sandwich-type structure of stoichiometry 2:1, heme–drug, is tentatively proposed. IR spectra and colorimetry data indicated that bisbenzamidines readily interact with heme in cell-free systems at pH 5.0 and 7.0.

Identifiants :
  • DOI : 10.1016/j.bmcl.2004.01.070
  • PMID : 15026037