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2022-07-16 - Colloque/Présentation - poster - Anglais - page(s) (A publier)

Bellaert Nellia , Crowley Michael, Blumberg Hilary, Rossignol Mandy , Deveney Christen, Tseng Wan-Ling, "Associations of Irritability and Anhedonia with Event-Related Potentials Measures of Reward Responsivity in Young Adults" in Conference of the International Society for Research on Emotion (ISRE), University of Southern California, Los Angeles, USA, 2022

  • Codes CREF : Psychopathologie (DI3513), Physiopsychologie et psychologie biologique [psychiatrie] (DI3500)
  • Unités de recherche UMONS : Psychologie cognitive et Neuropsychologie (P325), FPSE - Service du Doyen (P342)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
Texte intégral :

Abstract(s) :

(Anglais) Irritability and anhedonia are two prevalent symptoms of major depressive disorder (MDD); anhedonia is a cardinal symptom of MDD, and irritability is reported by 40-50% of adult patients with MDD (Perlis et al., 2005; Judd et al., 2013). Both irritability and anhedonia have been proposed to be underpinned by dysfunctional reward processing. While irritability is associated with increased reward responsivity (Brotman et al., 2018), anhedonia is linked to blunted striatal reactivity to reward receipt (Borsini et al., 2020). Despite their high co-occurrence and the paradox in their respective reward dysfunctions, no research to date has investigated how the presence of both symptoms are linked to reward processing. Therefore, the aim of our study is to investigate reward responsivity using event-related potentials (ERPs) in young adults (ages 18-25) with varying degrees of irritability and anhedonia. These symptoms are measured through the Brief Irritability Test and the Snaith-Hamilton Pleasure Scale, respectively. Reward responsivity is measured by the difference between the Feedback-Related Negativity to gain and loss feedback in the Doors task (Foti et al., 2011), termed the Reward Positivity. Mixed-effects model will test the unique and combined effects of irritability and anhedonia on Reward Positivity. Data collection is ongoing, and preliminary results will be presented at the conference. We expect reward responsivity to be unique for the combined irritability and anhedonia phenotype compared to those of irritability or anhedonia presenting alone. A more refined understanding of the pathophysiology of these potentially distinct MDD clinical profiles would provide new insights into the treatment of depression