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2014-10-09 - Colloque/Présentation - poster - Anglais - 1 page(s)

Rubio Magnieto Jenifer , Thomas Amandine, Clement Sebastien, Lazzaroni Roberto , Surin Mathieu , "Design of DNA – Conjugated Polymers hybrids: insights into the self-assembly" in Annual Meeting of SRC, Namur, Belgium, 2014

  • Codes CREF : Chimie des polymères de synthèse (DI131C)
  • Unités de recherche UMONS : Chimie des matériaux nouveaux (S817)
  • Instituts UMONS : Institut de Recherche en Science et Ingénierie des Matériaux (Matériaux), Institut de Recherche sur les Systèmes Complexes (Complexys)
  • Centres UMONS : Centre d’Innovation et de Recherche en Matériaux Polymères (CIRMAP)
Texte intégral :

Abstract(s) :

(Anglais) Water-soluble -conjugated polymers (CPs), in particular cationic polythiophenes (CPT), possess optical fingerprints very sensitive to their conformation and supramolecular assembly. In the last decade, the design of complex chemical systems based on these conjugated polymers and biomolecules as DNA has attracted many researchers. These hybrid supramolecular systems can be utilized for instance for the identification of proteins, and for the determination of very low DNA concentrations. Moreover, conjugated polymers-based biosensors can also be used for the detection of Single-Nucleotide Polymorphism in DNA hybridization experiments, to identify neurodegenerative diseases.1 Here, we present our recent results on the design and self-assembly based on of a new class of hybrid supramolecular structures. Via (chir)optical spectroscopy, we have studied three important processes for the functioning of hybridization biosensors: i) complexation, i.e. the formation of polyplex between the single-stranded DNA and CPT; ii) hybridization, i.e. the formation of a triplex structure by adding a complementary DNA sequence on a ssDNACPT complex, and iii) melting properties. The results indicate that sequence, length, and topology of DNA strongly influence the conformation of the final supramolecular complex, especially the chirality of the polymer backbone, with specific right- or left-handed assemblies within the supramolecular system.2

Identifiants :
  • FNRS : the grant n°2.4615.11-BINDER