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2014-05-01 - Article/Dans un journal avec peer-review - Anglais - 4 page(s)

Okusa Ndjolo Philippe , Stévigny Caroline, Névraumont Marie, Gelbcke Michel, Van Antwerpen P., Duez Pierre , "Ferulaldehyde and lupeol as direct and indirect antimicrobial compounds from Cordia gilletii (Boraginaceae) root barks" in Natural Product Communications, 9, 5, 619-622, Accepté pour publication

  • Edition : Natural Product Communications (OH)
  • Codes CREF : Chimie analytique (DI1314), Pharmacognosie (DI3410), Sciences pharmaceutiques (DI3400), Sciences exactes et naturelles (DI1000)
  • Unités de recherche UMONS : Chimie thérapeutique et Pharmacognosie (M136)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) Cordia gilletii De Wild (Boraginaceae), a medicinal plant used against infectious diseases in the Democratic Republic of Congo, was investigated for direct and indirect antimicrobial properties. On one hand, the methanol extract is active against many pathogenic bacteria, including resistant strains. Its bio-guided fractionation led to the isolation of ferulaldehyde; this compound showed antimicrobial and antioxidant properties that may support the activity we observed for the methanol extract and some of the traditional uses of C. gilletii. On the other hand, the n-hexane extract of root barks possesses indirect antimicrobial properties, enhancing the activity of antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). The fractionation of this extract led to the isolation of lupeol, which decreases the minimum inhibitory concentration of several antibiotics (4 to 8 fold) against MRSA and contributes to the effects observed for the raw n-hexane extract.


Mots-clés :
  • (Anglais) Cordia gilletii
  • (Anglais) Ferulaldehyde
  • (Anglais) Lupeol
  • (Anglais) Antimicrobial
  • (Anglais) Boraginaceae