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2016-06-09 - Colloque/Présentation - communication orale - Anglais - 1 page(s)

Simoes Loureiro Isabelle , Lefebvre Laurent , "Mini SKQ (Semantic Knowledge Questionnaire) : 12 questions to highlight semantic deterioration in Alzheimer's disease." in The 2016 Alzheimer's disease congress. 7th-9th June 2016, London, UK, 2016

  • Codes CREF : Psychopathologie (DI3513), Neurosciences cognitives (DI4296), Sciences cognitives (DI4290), Psychologie cognitive (DI4211)
  • Unités de recherche UMONS : Psychologie cognitive et Neuropsychologie (P325)
  • Instituts UMONS : Institut de recherche en sciences et technologies du langage (Langage), Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Mind & Health (CREMH)
Texte intégral :

Abstract(s) :

(Anglais) Mini SKQ (Semantic Knowledge Questionnaire): 12 questions to highlight semantic deterioration in Alzheimer’s disease Isabelle Simoes Loureiro and Laurent Lefebvre Cognitive psychology and neuropsychology department, Institute of health sciences and technologies, University of Mons Correspondence: Isabelle Simoes Loureiro, Cognitive psychology and neuropsychology department, University of Mons (UMONS), Place du Parc, 18, 7000, Mons. Email: isabelle.simoesloureiro@umons.ac.be Objective Semantic memory disturbance is, with episodic memory deficit, one of the first symptom in Alzheimer’s disease (AD). However, semantic knowledge is not always investigated in the neuropsychological assessment and is rather reflected through non-specific semantic measurements as through naming tasks. The Semantic Knowledge Questionnaire (SKQ) explores semantic impairments in AD patients. Initially proposed by Laiacona et al. (1933) and revised in a French and more concise form by Simoes Loureiro and Lefebvre (2015), SKQ assesses different levels of hierarchy and attributes in semantic memory by the mean of 120 questions about 30 objects (Q1: questions about general superordinate aspects; Q2: questions about intracategorical aspects; Q3: questions about perceptual attributes and Q4: questions about thematical/functional attributes). The objective of this work is to create a shorter version of SKQ, with the most discriminant questions to AD, in order to highlight semantic impairments during neuropsychological assessment. Method and results We administered SKQ in its full version (120 items) to 39 healthy senior (MMSE > or = 28) and 35 mild AD (MMSE>20). An item by item analysis was conducted to compare control group and AD group in order to pick up the most differentiated items between both groups with chi-square. 12 items discriminating both group at a level of significance of p=.001 were selected (three Q2; four Q3 and four Q4). We also performed correlational analyses for non-parametric data (Kendall’s Tau correlation) to ensure that the failure to these 12 items are well correlated with AD (p=.001). Finally, a Bravais-Pearson correlation analysis confirms the correlation between the score at mini-SKQ and the full version of SKQ (r=.992; p=.001). Conclusion The Mini-SKQ is a fast and easily administered questionnaire. Results indicated favorable psychometric indicators to screen semantic knowledge. The failure to the items of the mini-SKQ is highly correlated to AD. These first observations underlines that mini-SKQ could potentially be attractive for screening semantic memory deterioration.