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2021-11-19 - Article/Dans un journal avec peer-review - Anglais - 26 page(s)

Lamotte Laurie-Anne , Tafforeau Lionel , "How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity" in Viruses, 13, 11, 2309

  • Edition : Multidisciplinary Digital Publishing Institute (MDPI) (Switzerland)
  • Codes CREF : Virologie générale (DI3132)
  • Unités de recherche UMONS : Biologie cellulaire (S815)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé), Institut des Biosciences (Biosciences)
Texte intégral :

Abstract(s) :

(Anglais) Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechanisms to counteract this system to perform proper infection. Among IAV proteins, the non-structural protein NS1 is shown to be one of the main virulence factors involved in these viral hijackings. NS1 is notably able to inhibit the host’s antiviral response through the perturbation of ubiquitination in different ways, as discussed in this review.


Mots-clés :
  • (Anglais) NS1
  • (Anglais) innate immunity
  • (Anglais) ubiquitin
  • (Anglais) Influenza A virus