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2016-07-06 - Colloque/Présentation - communication orale - Anglais - 1 page(s)

Lenaerts Charline , Tuytten Robin, Bond Liz, Delporte Cédric, Van Antwerpen P., Blankert Bertrand , "A LC-MS assay for identification and quantification of marinobufagenin in human: a novel approach for preeclampsia risk evaluation" in MASCL, Salzburg, Austria, 2016

  • Codes CREF : Analyse et contrôle pharmaceutique (DI3450), Chimie analytique (DI1314), Sciences pharmaceutiques (DI3400)
  • Unités de recherche UMONS : Analyse pharmaceutique (M130)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Centre de Recherche UMONS-Ambroise Paré (UMHAP), Centre Interdisciplinaire de Spectrométrie de Masse (CISMA)

Abstract(s) :

(Anglais) Marinobufagenin (MBG) is a bufadienolide cardiac inotrope implicated in the early diagnosis of volume expansion-mediated hypertensive states such as preeclampsia. The enhanced production of MBG in preeclamptic patients has been described using poor-specific immunoassays. This demonstrates the need for a sensitive analytical method to detect MBG in plasma at low levels. The identification of marinobufagenin in human plasma (men, non-pregnant women and early-pregnant women) using a sensitive and specific LC-MS assay will be presented, leading to a promising perspective concerning the preeclampsia risk assessment. An observational clinical study is currently designed in order to confirm previous results.

Notes :
  • (Anglais) MSACL Travel Grant (Young Investigator)

Mots-clés :
  • (Anglais) LC-MS/MS
  • (Anglais) biomarker
  • (Anglais) Marinobufagenin
  • (Anglais) Bufo marinus
  • (Anglais) Preeclampsia