DI-UMONS : Dépôt institutionnel de l’université de Mons

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2008-01-01 - Article/Dans un journal avec peer-review - Anglais - 9 page(s)

Capouillez Aurélie, Decaestecker Christine, Filleul Olivier, Chevalier Dominique, Coppée Frédérique , Leroy Xavier, Belayew Alexandra , Saussez Sven , "Helicase-like transcription factor exhibits increased expression and altered intracellular distribution during tumor progression in hypopharyngeal and laryngeal squamous cell carcinomas" in Virchows Archiv : An International Journal of Pathology, 453, 5, 491-499

  • Edition : Springer International, Berlin (Germany)
  • Codes CREF : Biochimie (DI3112), Histologie (DI3212), Biologie moléculaire (DI3111), Cancérologie (DI3349)
  • Unités de recherche UMONS : Anatomie et Biologie cellulaire (M112), Biologie moléculaire (M122)
Texte intégral :

Abstract(s) :

(Anglais) The helicase-like transcription factor (HLTF) belongs to the SWI/SNF family of proteins that use the energy from adenosine triphosphate hydrolysis to remodel chromatin during a variety of cellular processes. HLTF is also involved in DNA repair. Using computer-assisted microscopy, the immunohistochemical expression of HLTF was determined using a series of 100 hypopharyngeal and 56 laryngeal squamous cell carcinomas (SCCs) compared to tumor-free epithelia (60 cases) and dysplasias (92 cases). In hypopharyngeal SCC tumor progression, increased HLTF expression was associated with the percentage of immunopositive epithelial tissue areas (p=0.02) and the staining intensity of the positive area (p=0.0005). In the cases of laryngeal lesions, the immunolabeling intensity of HLTF significantly decreased with malignancy (p=0.01). We also observed a significant shift of HLTF expression from the cytoplasm toward the nuclear compartment (p=0.0007). Our data reveal an association between the presence of HLTF and neoplastic progression of hypopharyngeal and laryngeal SCCs.

Identifiants :
  • ISSN : 0945-6317