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2013-03-12 - Colloque/Présentation - poster - Anglais - 1 page(s)

Paci Paula , Ris Laurence , Godaux Emile, "Expression of Arc protein in hippocampal organotypic cultures" in 7ème édition de la Matinée de Chercheurs, Mons, Belgique, 2013

  • Codes CREF : Sciences biomédicales (DI3200)
  • Unités de recherche UMONS : Neurosciences (M119)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) Memory is encoded in our brain by modifications of synaptic efficacy between neurons. Synaptic plasticity is the ability of synapses to modify their efficiency after previous neuronal activity. We are interested in one kind of synaptic plasticity which consists in a persistent increase of the synaptic transmission, called Long-Term Potentiation (LTP). Arc protein is implicated in memory and learning mechanisms. Arc is not expressed in the hippocampus. However, it is induced during LTP. To better understand the LTP mechanisms, expression and localization of Arc protein are studied in hippocampal organotypic slices which have the advantage of preserving the architectural organization of the hippocampus on the long term.