DI-UMONS : Dépôt institutionnel de l’université de Mons

Recherche transversale
(titres de publication, de périodique et noms de colloque inclus)
2013-10-06 - Colloque/Présentation - communication orale - Anglais - 1 page(s)

Rubio Magnieto Jenifer , Surin Mathieu , "Self-assembly of π-conjugated structures – DNA: A supramolecular engineering approach" in Conformational diversity and applications of G-quadruplexes, Sitges, Spain, 2012

  • Codes CREF : Chimie structurale (DI1317), Chimie des polymères de synthèse (DI131C), Photochimie (DI1325)
  • Unités de recherche UMONS : Chimie des matériaux nouveaux (S817)
  • Instituts UMONS : Institut de Recherche en Science et Ingénierie des Matériaux (Matériaux)
  • Centres UMONS : Centre d’Innovation et de Recherche en Matériaux Polymères (CIRMAP)

Abstract(s) :

(Anglais) Hybrid self-assembled structures combining biomolecules with synthetic (macro)molecules constitute an emerging class of materials, with applications in biosensors and drug delivery systems for instance. Recently, studies have been carried out on -conjugated polyelectrolytes binding to DNA, and fluorescence properties of the complexes have been exploited to detect complementary single-stranded DNA sequences.1 This concept has also been remarkably used to accurately determine DNA concentration down to nanomolar range, and to probe conformational changes of aptamer upon binding to human -thrombin.2 In this frame, we study the self-assembly of -conjugated oligomers or polymers with specific DNA structures (oligonucleotides), in order to elaborate novel hybrid materials possessing specific optical and (bio)recognition properties. With this aim, we develop a supramolecular engineering approach, which combine theoretical molecular modelling, (chir)optical spectroscopy, and scanning probe microscopy. This allows us to develop models of self-assembly and to establish a deep understanding of the structure-properties relationships in these supramolecular objects. In this talk, we will particularly highlight two approaches: i) the DNA base template approach, which deals with the base recognition properties to scaffold assemblies of -conjugated oligomers with specific 2D or 3D supramolecular organization, which is exploited to develop supramolecular wires on surfaces for organic electronics or to direct energy-transfer processes along DNA templates;3 ii) the polymer-DNA approach, which deals with the self-assembly of cationic polymers and functional nucleic acids, with the intention to construct highly selective chemo- and bio-sensors. For both approaches, we particularly highlight the role guanine scaffolds and G-quadruplexes structures in the self-assembly processes.