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2014-10-23 - Colloque/Présentation - communication orale - Anglais - 1 page(s)

Gabriele Sylvain , "May the force be with you: physical-chemistry controls cell mechanics" in 3rd NanoFar Autumn School, Brussels, Belgium, 2014

  • Codes CREF : Physico-chimie générale (DI1320), Biophysique (DI3113)
  • Unités de recherche UMONS : Laboratoire Interfaces et Fluides complexes (S885)
  • Instituts UMONS : Institut de Recherche sur les Systèmes Complexes (Complexys), Institut des Biosciences (Biosciences)

Abstract(s) :

(Anglais) Cell movement is a highly dynamic phenomenon that is essential to a variety of biological processes, such as the development of an organism (morphogenesis), wound healing, cancer metastasis and immune response. As a cell moves on a natural or synthetic matrix, it experiences various external forces, which include resistance from the surrounding medium, cell-substrate interaction forces, and internal forces that are generated by the cytoskeleton. A basic question we must address is therefore to know what force a cell will exert when moving on a foreign surface. To answer this question, important efforts have been directed during the last decades towards understanding the role of physico-chemical properties of cell matrices, such as the ligand species, lateral density and distribution of active sites, mechanical properties and micrometer- or nanometer-scale topography. During this course, I will describe some impressive progresses that have been made on the way cells respond dynamically to substrate properties, with an emphasis on the physical basis of the forces that govern the crawling of single cells.