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2010-05-19 - Colloque/Présentation - communication orale - Anglais - 1 page(s)

Yamashita M., Ozaki N., Yamashita J., Fujie M., Sugiyama M., Ogawa K., Aoki T., Ito S., Reddy V.K., Yamada M., Aoshima Kengo, Kamikage N., Ravi Sankar A.U., Yu G., Kiyofuji K., Takehara Y., Sakahara H., Takayanagi H., Laurent Sophie , Burtea Carmen , Vander Elst Luce , Muller Robert , "Researches on sugar modified dendritic Gd-DTPA complexes for MRI contrast agents" in Contrast-enhanced biomedical imaging, 12th Bi-Annual Conference on Contrast Agents and Multimodal Molecular Imaging, Mons, Belgique, 2010

  • Codes CREF : Résonance magnétique nucléaire (biophysique) (DI131B), Sciences biomédicales (DI3200), Chimie de coordination (DI1319), Pharmacocinétique (DI3431), Chimie organique (DI1313)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé), Institut des Biosciences (Biosciences)
  • Centres UMONS : Centre de Recherche en Microscopie et Imagerie Médicale (CMMI)

Abstract(s) :

(Anglais) Purpose The Gd-DTPA complex (Magnevist) is one of the most efficient and safest contrast agents for MR imaging. It has, however, some imperfections, among them poor blood pool behavior and unspecificity. To improve the weak points, the Gd-DTPA complex was modified by sugar residue to provide a recognizing site of blood components and enhance the imaging potential of MRI contrast agent by constructing sugar dendritic structure, which will work as a DDS of Gd-DTPA complex. Materials and Methods Dendritic sugar modified Gd-DTPA complexes were prepared as exemplified by Figure 1 for Gd-DTPA complex as the core with dendritic four sugars as the terminal. Results Protected four-sugar-modified Gd-DTPA complex, protected twelve-sugar-modified Gd-DTPA complex, hydrolyzed four sugar modified Gd-DTPA complex, etc. were evaluated in vitro and in vivo methods. Conclusion Sugar modified Gd-DTPA complexes have larger r1 values and enhanced better in vivo images. Especially hydrolyzed sugar-modified Gd-DTPA, DEN-OH, enhanced blood vessels and tumors more clearly than Gd-DTPA, therefore, the MRI contrast agent should be developed for innovating in MR Angiography (MRA) and diagnosis of early stage tumors, and then improving QOL of patients.
   
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