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2014-02-24 - Article/Dans un journal avec peer-review - Anglais - 13 page(s)

Pardo Antonelle , Mespouille Laetitia , Blankert Bertrand , Dubois Philippe , Duez Pierre , "Molecularly imprinted polymers: compromise between flexibility and rigidity for improving capture of template analogues" in Chemistry, 20, 12, 3500-3509

  • Edition : John Wiley & Sons (United Kingdom)
  • Codes CREF : Chimie des polymères de synthèse (DI131C), Pharmacognosie (DI3410), Sciences pharmaceutiques (DI3400), Techniques séparatives (DI2729)
  • Unités de recherche UMONS : Matériaux Polymères et Composites (S816), Analyse pharmaceutique (M130), Chimie thérapeutique et Pharmacognosie (M136)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) New synthesis strategies of molecularly imprinted polymers (MIPs) were developed in order to mimic the flexibility and mobility exhibited by receptor/enzyme binding pockets. The MIPs were prepared through bulk polymerization by using quercetin as template molecule, acrylamide (AA) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linker with tetrahydrofuran (THF) as porogen. The 10 innovative grafting of polyethylene glycol (PEG) moieties on the imprinted cavities allowed obtaining MIPs which exhibit cross-reactivities towards a group of structural analogs instead of an absolute specificity for the template. This synthesis strategy could be applied to design molecular recognition for molecules based on a congruent pharmacophore and therefore appears as a highly promising tool for drug discovery.