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2019-06-01 - Article/Dans un journal avec peer-review - Anglais - 14 page(s)

Schorsch Julien, Castro Cristiana , Couto Luís, Nobre Clarisse, Kinnaert Michel, "Optimal control for fermentative production of fructo-oligosaccharides in fed-batch bioreactor" in Journal of Process Control

  • Edition : Butterworth Scientific (United Kingdom)
  • Codes CREF : Biotechnologie (DI3800), Génie chimique (DI2721)
  • Unités de recherche UMONS : FPMs - Service du Doyen (F100), Génie des Procédés chimiques et biochimiques (F505), Thermodynamique, Physique mathématique (F506)
  • Instituts UMONS : Institut des Biosciences (Biosciences)
Texte intégral :

Abstract(s) :

(Anglais) The production of high-content fructo-oligosaccharides by fermentation in a fed-batch bioreactor is considered. Fed-batch scenario allows to reduce inhibition mechanisms caused by the presence of by-products, such as glucose, while maximizing biomass production. The determination of the feed flow rate profile that maximizes the concentration of fructo-oligosaccharides is performed by resorting to the maximum principle of Pontryagin. The optimization procedure takes into account inequality constraints on the state and control variables and allows the determination of the unspecified final fermentation time corresponding to maximal fructo-oligosaccharides content. The performance of the approach is demonstrated by simulations in the case of fructo-oligosaccharide production by Aspergillus sp.