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2021-12-06 - Article/Dans un journal avec peer-review - Anglais - 27 page(s)

Bisconti Marie , Simon Jean-François, Grassi Sarah, Leroy Baptiste , Martinet Baptiste , Arcolia Vanessa, Isachenko Vladimir, Hennebert Elise , "Influence of risk factors for male infertility on sperm protein composition" in International Journal of Molecular Sciences

  • Edition : Multidisciplinary Digital Publishing Institute (MDPI) (Switzerland)
  • Codes CREF : Biologie moléculaire (DI3111), Biologie cellulaire (DI311D)
  • Unités de recherche UMONS : Biologie cellulaire (S815)
  • Instituts UMONS : Institut des Biosciences (Biosciences)
  • Centres UMONS : Centre de Recherche UMONS-Ambroise Paré (UMHAP)
Texte intégral :

Abstract(s) :

(Anglais) Male infertility is a common health problem that can be influenced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. These effects have been largely demonstrated on sperm parameters (e.g., motility, numeration, vitality, DNA integrity). In addition, several studies showed the deregulation of sperm proteins in relation to some of these factors. This review inventories the literature related to the identification of sperm proteins showing abundance variations in response to the four risk factors for male infertility that are the most investigated in this context: obesity, diabetes, tobacco smoking, and exposure to bisphenol-A (BPA). First, we provide an overview of the techniques used to identify deregulated proteins. Then, we summarise the main results obtained in the different studies and provide a compiled list of deregulated proteins in relation to each risk factor. Gene ontology analysis of these deregulated proteins shows that oxidative stress and immune and inflammatory responses are common mechanisms involved in sperm alterations encountered in relation to the risk factors.