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2020-01-19 - Livre/Chapitre ou partie - Anglais - 20 page(s)

Carette Julie , Nachtergael Amandine , Duez Pierre , El Jaziri Mondher, Rasamiravaka Tsiry, "Natural compounds inhibiting pseudomonas aeruginosa biofilm formation by targeting quorum sensing circuitry" in Carette Julie , Nachtergael Amandine , Duez Pierre , El Jaziri Mondher, Rasamiravaka Tsiry, "Bacterial Biofilm" , Dincer S., Özdenefe M.S., Arkut A., 978-1-78985-899-0

  • Edition : IntechOpen
  • Codes CREF : Pharmacognosie (DI3410), Sciences pharmaceutiques (DI3400), Microbiologie et protistologie [bacteriol.,virolog.,mycolog.] (DI3130)
  • Unités de recherche UMONS : Chimie thérapeutique et Pharmacognosie (M136)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
Texte intégral :

Abstract(s) :

(Anglais) The biofilm lifestyle mode certainly represents one of the most successful behaviors to facilitate bacterial survival in diverse inhospitable environments. Conversely, the ability of bacteria to develop effective biofilms represents one of the major obstacles in the fight against bacterial infections. In Pseudomonas aeruginosa, the biofilm formation is intimately connected to the quorum sensing (QS) mechanisms, a mode of cell-to-cell communication that allows many bacteria to detect their population density in order to coordinate common actions. In this chapter, we propose an overview (i) on P. aeruginosa QS mechanisms and their implication in biofilm formation; and (ii) on natural products that are known to interfere with these QS mechanisms, subsequently disrupting biofilm formation. The concluding remarks focus on perspectives of these compounds as possible antibiotherapy adjuvants.