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2009-01-01 - Article/Dans un journal avec peer-review - Anglais - 7 page(s)

Saussez Sven , Decaestecker Christine, Cludts Stéphanie, Ernoux Perle, Chevalier Dominique, Smetana Karel, André Sabine, Leroy Xavier, Gabius Hans-Joachim, "Adhesion/growth-regulatory Tissue Lectin Galectin-1 in Relation to Angiogenesis/lymphocyte Infiltration and Prognostic Relevance of Stromal Up-regulation in Laryngeal Carcinomas" in Anticancer Research, 29, 1, 59-65

  • Edition : JG Delinassios Anticancer Research, Athens (Greece)
  • Codes CREF : Histologie (DI3212), Cancérologie (DI3349)
  • Unités de recherche UMONS : Anatomie et Biologie cellulaire (M112)
Texte intégral :

Abstract(s) :

(Anglais) Background: Galectin-1 has been found to modulate lymphocyte invasion in inflammation and to be involved in angiogenesis in models, thus prompting examination of its clinical relevance in laryngeal cancer. Patients and Methods: Immunohistochemical processing of tissue sections (n=53) from patients with stage I/II (n=35) and stage IV (n=18) laryngeal squamous cell carcinoma (LSCC) with a specific anti-galectin-1 antibody and monitoring of CD45/CD31 positivity was combined with quantitative morphometric analysis. Results: Lectin presence in the tumor and endothelial cells was positively correlated, while a negative relationship to the number of CD45-positive lymphocytes was demonstrated. No association was seen with the extent of neovascularization. The mean optical density (MOD) of lectin-dependent staining in the tumor stroma was significantly increased compared to normal stroma. Conclusion: Galectin-1 was not associated with angiogenesis in the studied cohort while galectin-1 in endothelial cells may negatively influence lymphocyte invasion and the mean optical density for the stromal galectin-1 signal is up-regulated in tumors.

Identifiants :
  • PMID : 19331133
  • ISSN : 0250-7005