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2019-06-23 - Colloque/Présentation - poster - Anglais - 1 page(s)

Maroil Dorian, Colet Jean-Marie , "Metabolomics in rat models of hypertension" in Metabolomics 2019, La Haye, Pays-Bas, 2019

  • Codes CREF : Médecine pathologie humaine (DI3300)
  • Unités de recherche UMONS : Biologie humaine et Toxicologie (M125)
Texte intégral :

Abstract(s) :

(Anglais) Hypertension is a complex and multi-factorial disease and its chronical form affects more than one billion people worldwide. Hypertension may become very critical as it is a major risk factor for cardiovascular morbidity and mortality. Most of hypertension cases are not a consequence of another disease but due to genetic, lifestyle or environmental factors Sometimes, it may also develop after renal failure. Metabolomics is a powerful tool to evaluate global metabolic perturbations in relation with disease, toxicity or treatments. It has proved very helpful for the follow up and identification of early potential biomarkers of these conditions. In order to identify underlying mechanisms involved in the onset of hypertension, we compared the metabolomics signature of either spontaneous or chemically-induced rat models of hypertension. Hypertension was induced in rats by oral administration of NO synthase inhibitor, L-NAME, through the drinking water for 4 weeks. This treatment not only increased the blood pressure but also reduced the renal function. The second model was based on Spontaneously hypertensive (SHR) rats which developed hypertension at the age of 6 weeks. The comparison of metabonomic signatures obtained by proton NMR spectroscopy of urine and serum samples collected from both rat models highlighted some common metabolic patterns which could be further developed as potential biomarkers of this pathology