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2019-06-21 - Colloque/Présentation - communication orale - Anglais - 1 page(s)

TCHEOUBI Sègbédé Edgard Roméo, AKPOVI Casimir D, FIOGBE Salomon EM, KOUGNIMON Fifamè EE, SEGBO Julien AG, SAGBO Gratien G, Burtea Carmen , AGBANGLA Clément, "Gestational diabetes mellitus is associated with a decrease in calcium and glucose levels in newborn" in 2ème Journées Africaines d'Endocrinologie clinique, Abidjan, Côte d'Ivoire, 2019

  • Codes CREF : Sciences biomédicales (DI3200), Endocrinologie (DI3322), Diabétologie (DI3373)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) Background: Glucose and calcium imbalance represents a common metabolic issue facing neonate that can lead to irreversible brain damages. Abnormal calcium homeostasis plays an important role in the development of diabetes. The aim of this study was to determine whether blood glucose and calcium levels at birth are affected by gestational diabetes mellitus. Methods: A case-control study was conducted in infants from diabetic mothers (IDM) and non-diabetic mothers (NDM). Blood glucose is measured by Glucose oxidase method and calcium by Arsenazo III with Elitech reagents (Puteaux, France) on samples taken at birth. Results: The study included 270 newborns of which 21 (7.77%) IDM, 50.37% male and 28.89% preterm, all from NDM. 8.52% (91.30% of IDM against 8.70% from NDM) suffered from macrosomia. Glycemia was lower in preterm (42±3 mg/dl; p <0.001) and macrosomic newborns (35±5 mg/dl; p <0.001) compared to normal neonates (75mg±3mg/dl). Calcemia was also lower in preterm (7.75±0.16 mg/dl; p <0.001) and macrosomic newborns (7.76±0.32 mg/dl; p <0.001) compared to normal (8.84±0.09 mg/dl). Blood glucose (38±5 mg/dl vs. 64±3 mg/dl; p <0.01) and calcium (7.71±0.27 mg/dl vs. 8.4.4±0.08 mg/dl; p <0.05) were significantly lower in IDM compared to NDM. Glycemia and calcemia showed a positive correlation in IDM (r =0.878, p<10-6) and macrosomic newborns (r =0.878, p<10-6). Conclusion: Our results showed that hypoglycemia is associated with hypocalcemia in newborns to diabetic mothers.


Mots-clés :
  • (Anglais) Benin
  • (Anglais) glycemia
  • (Anglais) Gestational diabetes mellitus
  • (Anglais) calcemia
  • (Anglais) newborn