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2013-12-02 - Colloque/Présentation - poster - Anglais - 1 page(s)

Henoumont Céline , Lipani Estelle , Laurent Sophie , Muller Robert , Vander Elst Luce , "Study of the silica nanoparticle surface by NMR" in 12ème YBMRS, Blankenberge, Belgique, 2013

  • Codes CREF : Résonance magnétique nucléaire (biophysique) (DI131B)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé), Institut des Biosciences (Biosciences)
  • Centres UMONS : Centre de Recherche en Microscopie et Imagerie Médicale (CMMI)

Abstract(s) :

(Anglais) Research in magnetic resonance imaging (MRI) has been evolving in the past years towards molecular imaging, which allows an earlier diagnosis of some diseases by the detection of molecules that are expressed, or overexpressed, in pathological conditions. Therefore, targeted contrast agents, bearing one or several vectors, are needed. Nanoparticles represent a very attractive platform for molecular imaging by MRI because they allow the grafting of several vectors, which offers the possibility of a more efficient recognition of the molecular contrast agent by its target (concept of multivalency). That is the reason why our laboratory is developing silica nanoparticles, as a platform able to be grafted with paramagnetic contrast agents (such as gadolinium complexes) and with small vectors targeting a specific pathology1. Polyethylene glycol (PEG) has also to be added at the surface of the particles to avoid the non specific capture of the particles by the macrophages. An important challenge remains however the complete characterization of the nanoparticle surface. In this aim, NMR appears to be a very interesting tool, especially the DOSY spectra which allow to characterize the diffusion properties of the molecules grafted on the nanoparticle surface. A decrease of their diffusion coefficients should indeed be observed after the grafting on the nanoparticle. This technique has been applied here to study the grafting of PEG on the surface of silica nanoparticles. 1. Lipani, E., Laurent, S., Surin, M., Vander Elst, L., Leclère, P., Muller, R.N. Langmuir 2013, 29(10), 3419-3427.