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2014-05-01 - Article/Dans un journal avec peer-review - Anglais - 17 page(s)

Bunel Valérian, Ouédraogo Moustapha, Nguyen Anh-Tho, Stévigny Caroline, Duez Pierre , "Methods applied to the in vitro primary toxicology testing of natural products: State of the art, strengths and limits" in Planta Medica, 80, 1210-1226, http://dx.doi.org/10.1055/s-0033-1360273

  • Edition : Georg Thieme Verlag (Germany)
  • Codes CREF : Pharmacognosie (DI3410), Sciences pharmaceutiques (DI3400), Sciences exactes et naturelles (DI1000), Toxicologie pharmaceutique (DI3440), Biologie cellulaire (DI311D)
  • Unités de recherche UMONS : Chimie thérapeutique et Pharmacognosie (M136)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) The present review attempts to build up a comprehensive picture of the major primary techniques used to screen and assess the cytotoxicity of plant complex mixtures. These can be based on metabolic activity, on membrane integrity, on morphological features, on cell growth; the type of cell death can also be established from more or less specific events (e.g., apoptosis, autophagy, DNA damage detection, reactive oxygen species involvement). This review will discuss the benefits, the difficulties, and the challenges that may occur along cytotoxicity testing of raw extracts and isolated natural compounds.

Identifiants :
  • DOI : 10.1055/s-0033-1360273

Mots-clés :
  • (Anglais) toxicity screening
  • (Anglais) cytotoxicity
  • (Anglais) biological assays
  • (Anglais) pitfalls
  • (Anglais) guidelines
  • (Anglais) natural products