DI-UMONS : Dépôt institutionnel de l’université de Mons

Recherche transversale
(titres de publication, de périodique et noms de colloque inclus)
2020-09-17 - Travail avec promoteur/Doctorat - Anglais - 197 page(s)

Loyez Médéric , "Cancer biomarkers sensing using all-in fiber plasmonic assays", Wattiez Ruddy (p) , Caucheteur Christophe , soutenue le 2020-09-17

  • Codes CREF : Capteurs et périphériques (DI2563)
  • Jury : Voué Michel (p) , Mégret Patrice , DeRosa Maria, Remmelink Myriam, Lammertyn Jeroen
  • Unités de recherche UMONS : Protéomie et Microbiologie (S828), Electromagnétisme et Télécommunications (F108)
  • Instituts UMONS : Institut de Recherche en Science et Ingénierie des Matériaux (Matériaux)
  • Centres UMONS : Ingénierie des matériaux (CRIM)

Abstract(s) :

(Anglais) Biosensing is a multidisciplinary field of research, combining biotechnology with infinite sensing modalities. This thesis investigates the use of optical fibers for the detection of cancer biomarkers. To reach biosensing features, photo-imprited patterns are impemented inside the core of standard telecommunication optical fibers. These structures, calles tilted fiber bragg gratings (TFBGs) are able toexcite surface plasmons (SPR) in the near infrared range when a thin gold film of few tens of nanometers is added on the fiber surface. Different sensing configurations were tested to optimize the dettion of lung cancer biomarkers at very low concentration. In this contex, our probes were extensively tested ex-vivo on freshl resected human lung tissues, but also in vivo yielding the first SPR excitation in a living organism. The optrodes were also tested against circulating breast cancer celles, with the implemntation of gold nanoparticles providing plasmonic enancements. This work demonstrates the high potential of SPR-TFBGs to be further used for biomedical applications that require direct measurements in confined and poorly accessile environments, in a less invasive way than the current available techniques.