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2014-06-30 - Article/Dans un journal avec peer-review - Anglais - 23 page(s)

Costa Leal Miguel, Sheridan Christopher, Osinga Ronald, Dionísio Gisela, Rocha Rui Jorge Miranda, Silva Bruna, Rosa Rui, Calado Ricardo, "Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery" in Marine Drugs, 12, 7, 3929–3952

  • Edition : Multidisciplinary Digital Publishing Institute (MDPI) (Switzerland)
  • Codes CREF : Biotechnologie (DI3800), Pêches et aquacultures (DI3680), Sciences pharmaceutiques (DI3400), Produits pharmaceutiques (DI3493), Microbiologie et protistologie [bacteriol.,virolog.,mycolog.] (DI3130)
  • Unités de recherche UMONS : Biologie des Organismes Marins et Biomimétisme (S864)
  • Instituts UMONS : Institut des Biosciences (Biosciences)
Texte intégral :

Abstract(s) :

(Anglais) The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the “blue gold” in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.

Identifiants :
  • DOI : 10.3390/md12073929
  • FNRS : F3/5/5 - A2/5 - MCF/DM - A115

Mots-clés :
  • (Anglais) marine natural products
  • (Anglais) microbial symbionts
  • (Anglais) pharmaceuticals
  • (Anglais) marine invertebrates
  • (Anglais) aquaculture