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2021-05-25 - Colloque/Présentation - communication orale - Anglais - page(s)

Delpierre Antoine , Deroux Chloé, Ris Laurence , Decleves Anne-Emilie , Legrand Alexandre , Villers Agnès , Tassin Alexandra , "Muscle-to-Brain communication in the context of obesity: impact of physical exercise?" in PhysPhar Spring meeting, Belgium, 2021

  • Codes CREF : Physiologie générale (DI3220)
  • Unités de recherche UMONS : Physiologie et réadaptation respiratoire (M117), Neurosciences (M119), Biochimie métabolique et moléculaire (M122)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Centre de Recherche UMONS-Ambroise Paré (UMHAP)
Texte intégral :

Abstract(s) :

(Anglais) Muscle-to-Brain communication in the context of obesity: impact of physical exercise? A. Delpierre (1), C. Deroux (2), L. Ris (2), A-E. Declèves (3), A. Legrand (1), A. Villers (2) and A. Tassin (1) (1) Lab. of Respiratory Physiology and Rehabilitation, UMONS (2) Lab. of Neurosciences, UMONS (3) Lab. of Metabolic and Molecular Biochemistry, UMONS Exercise training (ET) has a positive effect on brain health. During ET, skeletal muscle releases specific myokines among them potential regulators of hippocampal function, like Irisin, released by cleavage of FNDC5. Also expressed in the brain, FNDC5 contributes to increase the level of brain-derived neurotrophic factor (BDNF). However, the contribution of muscle-derived Irisin on cognitive function remains controversial, as well as the influence of obesity or ET modalities. The goal of our study is to determine (i) inter-relationships between FNDC5/Irisin pathway and cognition depending on ET modalities and (ii) whether muscle-to-brain crosstalk is altered in the context of obesity. Two ET modalities were compared in Low-Fat (LF) and High-Fat (HF) fed mice: volontary (enriched environment) and forced ET (endurant). Irisin plasmatic level is increased by ET, whatever ET modality or diet. As concern FNDC5, volontary ET is associated to an increased protein level in LF but not in HF mouse muscles while forced ET does not modify FNDC5 protein level in muscular or brain tissues. Enrichment in mice improves spatial learning and memory. However, the BDNF protein level is not modified by volontary ET in the cortex and hippocampus. Forced ET does not modify spatial learning and memory and BDNF protein level in the hippocampus. However, BDNF protein level is increased in the brain cortex by endurance- training and surprisingly, by HF diet. In conclusion, ET increases Irisin plasmatic level and enrichment improves cognitive function in mice. FNDC5 protein level depend on training modalities, is tissue-specific and influenced by diet.