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2004-09-06 - Article/Dans un journal avec peer-review - Anglais - 4 page(s)

Vanden Eynde Jean-Jacques , Mayence A., Huang T.L., Collins M.S., Rebholz S., Walzer P.D., Cushion M.T., "Novel Bisbenzamidines as Potential Drug Candidates for the Treatment of Pneumocystis Carinii Pneumonia" in Bioorganic & Medicinal Chemistry Letters, 14, 17, 4545 - 4548

  • Edition : Elsevier Science, Oxford (United Kingdom)
  • Codes CREF : Chimie organique (DI1313)
  • Unités de recherche UMONS : Chimie organique (S836)
Texte intégral :

Abstract(s) :

(Anglais) A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.

Identifiants :
  • PMID : 15357989
  • DOI : 10.1016/j.bmcl.2004.06.034