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2005-01-01 - Article/Dans un journal avec peer-review - Anglais - 9 page(s)

Segers J., Le Duc G., Laumonier C., Tropres I., Vander Elst Luce , Muller Robert , "Evaluation of Gd-EOB-DTPA uptake in a perfused and isolated mouse liver model - Correlation between magnetic resonance imaging and monochromatic quantitative computed tomography" in Investigative Radiology, 40, 9, 574-582

  • Edition : Lippincott Williams & Wilkins, Hagerstown (MD)
  • Codes CREF : Pharmacocinétique (DI3431), Imagerie médicale, radiologie, tomographie (DI3243)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
Texte intégral :

Abstract(s) :

(Anglais) Objectives: The aim of this work was to quantitatively evaluate the pharmacokinetic pattern of Gd-EOB-DTPA in a model of isolated and perfused mouse liver by using magnetic resonance imaging (MRI) and monochromatic quantitative computed tomography (MQCT). Materials and Methods: For MQCT, perfusions were realized with the gallbladder spared; for MRI, with gallbladder spared, severed, or clamped. Inductively coupled plasma (ICP) was performed at the end of the imaging protocols. Results: MQCT, MRI, and ICP showed that perfused mice livers with spared gallbladder can be divided in 2 groups depending on their uptake profile of the contrast agent. Livers with severed gallbladders behave as the group internalizing more contrast agent, whereas Gd-EOB-DTPA uptake looks impaired in the case of a clamped gallbladder. Conclusions: For the first time, MQCT and MRI have been performed in parallel to investigate the same physiological problem. The existence of 2 liver groups seems to be the result of some instability of the protocol likely to be related to surgery.

Identifiants :
  • ISSN : 0020-9996
  • PMID : 16118550