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2007-11-26 - Article/Dans un journal avec peer-review - Anglais - 6 page(s)

Legeay J.-C., Vanden Eynde Jean-Jacques , Bazureau J.P., "Sequential Synthesis of a New Analogue of Amlodipine Bearing a Short Amino Polyethyleneglycol Chain" in Tetrahedron, 63, 48, 12081 – 12086

  • Edition : Pergamon Press, Oxford (United Kingdom)
  • Codes CREF : Chimie organique (DI1313)
  • Unités de recherche UMONS : Chimie organique (S836)
Texte intégral :

Abstract(s) :

(Anglais) 3-Ethyl 5-methyl 2-[(2-(2-(2-aminoethoxy)ethoxy)ethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate as new analogue of amlodipine was prepared in five steps with an overall yield of 22%. The 1,4-dihydropyridine nucleus was built in two steps via Knoevenagel reaction and the amino group of this analogue has been prepared in good yield by Staudinger reduction of the azido 1,4-dihydropyridine precursor in the last step.

Identifiants :
  • DOI : 10.1016/j.tet.2007.08.111