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2007-01-01 - Article/Dans un journal avec peer-review - Anglais - 8 page(s)

Yu G., Yamashita M., Aoshima K., Kobayashi M., Kato T., Kamikage N., Takahashi M., Takayanagi H., Oshikawa T., Laurent Sophie , Burtea Carmen , Vander Elst Luce , Muller Robert , Takehara Y., Sakahara H., "Studies on preparation and characterization of novel MRI contrast agents for targeting organs and blood vessels" in HETEROCYCLIC COMMUNICATIONS, 13, 2-3, 101-108

  • Codes CREF : Résonance magnétique nucléaire (biophysique) (DI131B), Chimie organique (DI1313), Imagerie médicale, radiologie, tomographie (DI3243)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)

Abstract(s) :

(Anglais) To improve the poor properties of currently clinically used MRI contrast agent of Gd-DTPA (Gadolinium-Diethylenetriamine-N,N,N',N",N"-pentaacetic acid) complex, sugar dendritic derivatives which contains Gd-DTPA as the core part and four or twelve sugars as the terminal part, dendrimer 8(Gd-DTPA-D1Glc(OAc)) or dendrimer 10(Gd-DTPA-D2Glc(OAc)), respectively, were prepared. From the result of relaxivity profile of these Gd complexes depending on temperature and magnitude of magnetic field, the smaller size MRI contrast agent of Gd-DTPA, 8(Gd-DTPA-D1Glc(OAc)), showed similar behavior to that of Gd-DTPA and the dendrimer constructs DDS of Gd-DTPA and was proven to have the improved properties for MR imaging of blood vessel (MRA) as well as for targeting specific organs.

Identifiants :
  • ISSN : 2191-0197

Mots-clés :
  • (Anglais) MRI contrast agents
  • (Anglais) magnetic resonance imaging
  • (Anglais) nuclear magnetic resonance