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2008-10-23 - Divers/Brevet - Français - 73 page(s)

Port Marc, Rousseaux Olivier, Muller Robert , Burtea Carmen , "Compounds for diagnosing apoptosis"

  • Codes CREF : Résonance magnétique nucléaire (biophysique) (DI131B), Sciences biomédicales (DI3200), Cardiologie et circulation (DI3321), Biologie moléculaire (DI3111), Chimie de coordination (DI1319), Chimie organique (DI1313), Chimie des colloïdes (DI1329), Imagerie médicale, radiologie, tomographie (DI3243)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
Texte intégral :

Abstract(s) :

(Anglais) The invention relates to a compound of the following general formula (I): Signal-Link-Peptide (I) in which Signal is a signal entity, Link is present or absent and is a chemical bond, and Peptide is a peptide including an apoptosis targeting peptide, the apoptosis targeting peptide being selected from the peptides of the following formula and the functional equivalents thereof: - X1-X2-X3-X4-X5-X6 (1) (SEQ ID No 1) in which X1 and X2 are each independently leucine or isoleucine, X3 and X4 are lysine, X5 is proline and X6 is phenlyalanine, advantageously the peptide L-I-K-K-P-F (SEQ ID No 11) and the functional equivalents thereof; - D-A-H-S-X7-S (2) (SEQ ID No 2) in which X7 is phenlyalanine or leucine; - P-G-D-L-X8-X9 (3) (SEQ ID No 3) in which X8 is serine or valine and X9 is threonine or arginine; - H-G-X10-L-S-X11 (4) (SEQ ID No 4) in which X10 is aspartic acid or histidine and X11 is threonine or isoleucine; - V-L-G-E-R-G (5) (SEQ ID No 5); and the pharmaceutically acceptable salts of said compounds.


Mots-clés :
  • (Anglais) molecular imaging
  • (Anglais) MRI contrast agents
  • (Anglais) molecular targeting
  • (Anglais) apoptosis
  • (Anglais) peptides
  • (Anglais) atherosclerosis