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2017-03-25 - Article/Dans un journal avec peer-review - Anglais - 10 page(s)

Bakari A, Mwamba M, Lumbu Simbi J.-B., Okusa P.N., Duez Pierre , Kahumba Byanga J., "Hypoglycemic and antihyperglycemic activities of nine medicinal herbs used as antidiabetic in the region of Lubumbashi (D.R. Congo)" in Phytotherapy Research, http://dx.doi.org/10.1002/ptr.5814

  • Edition : Wiley, Chichester (United Kingdom)
  • Codes CREF : Chimie analytique (DI1314), Pharmacognosie (DI3410), Sciences pharmaceutiques (DI3400), Pharmacologie (DI3420)
  • Unités de recherche UMONS : Chimie thérapeutique et Pharmacognosie (M136)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
Texte intégral :

Abstract(s) :

(Anglais) The aim of this study was to assess the hypoglycemic and antihyperglycemic activities of 9 plants used as antidiabetic treatments in Lubumbashi and its surroundings. Those are: Albizia adianthifolia, Azanza garckeana, Cassia occidentalis, Cassia sieberiana, Erythrina abyssinica, Gladiolus klattianus, Rauvolfia caffra, Strychnos spinosa and Vitex madiensis. Aqueous extracts, obtained by decoction and maceration, were administered (500mg/ kg) per os to guinea pigs (Cavia porcellus), both in glucose-baseline conditions and in oral glucose tolerance test conditions (OGTT; glucose, 2g/kg; follow-up over 210min). For OGGT experiments, area under the curve (AUC) of blood glucose levels, maximum glucose concentration (Cmax) and time to reach Cmax (Tmax) were used to compare test groups with the control conditions (glucose group). In hypoglycemic tests, only three species induced significant (p < 0.001) lowerings of normal glycemia, Albizia adianthifolia (33% reduction), Cassia occidentalis (32%) and Vitex madiensis (43%); in the same conditions, the positive control glibenclamide (6mg/kg) induced a blood glucose lowering of 55%. In OGTT conditions all tested herbs were active with the highest inhibition of glycaemia increases for: V. madiensis (62%) and Albizia adianthifolia (57%), compared to the hyperglycemic inhibition rate of glibenclamide (50%). OGGT conditions appears as essential to detect the extracts most interesting for clinical use. These data support the use of studied plants for diabetes treatment in traditional Congolese medicine and indicate a good knowledge of tradipraticians in the field.