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2018-07-16 - Colloque/Présentation - poster - Anglais - 1 page(s)

Lefebvre Laurent , Simoes Loureiro Isabelle , "A screening tool for evaluating the semantic deterioration in Alzheimer's disease : The mini SKQ (Semantic Knowledge Questionnaire)." in 2nd Innovations and state of the art in dementia research., 64, Valencia, July 16-18., Espagne, 2018

  • Codes CREF : Psychopathologie (DI3513), Neurosciences cognitives (DI4296), Sciences cognitives (DI4290), Psychologie cognitive (DI4211)
  • Unités de recherche UMONS : Psychologie cognitive et Neuropsychologie (P325)
  • Instituts UMONS : Institut de recherche en sciences et technologies du langage (Langage), Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Centre de Recherche UMONS-Ambroise Paré (UMHAP), Mind & Health (CREMH)
Texte intégral :

Abstract(s) :

(Anglais) Background It is now well-accepted that semantic memory disturbance is one of the first symptom in Alzheimer ‘disease (AD). However, this ability is not always investigated in the traditional neuropsychological assessment and is rather evaluated through non-specific semantic measurements, as through naming tasks. The objective of the Semantic Knowledge Questionnaire (SKQ) was to explore semantic impairment in AD patients. Proposed by Laiacona et al.[1], revised in a French by Simoes Loureiro and Lefebvre[2], SKQ assesses some levels of hierarchy and attributes in semantic memory by the mean of 120 questions about 30 objects. The score for each question is 1 (expected answer) or 0 (error). The objective of this work is now to create a brief version of our SKQ, with the most discriminant questions to AD, in order to be easily used in clinical environment. Method and results We administered SKQ to 39 healthy senior (MMSE > or = 28) and 35 mild AD (MMSE>20). An item by item analysis were conducted to compare our groups in order to pick up the most differentiated items. 12 items discriminating both group at a level of significance of p=.001 (by a khi-square analysis) were selected (4 questions about intracategorical aspects; 4 questions about perceptual attributes and 4 questions about thematical/functional attributes). We also performed correlational analyses for non-parametric data (Kendall’s Tau correlation) to ensure that the failure to these 12 items are well correlated with AD (p=.001). Finally, a Bravais-Pearson correlation analysis confirms the correlation between the score at mini-SKQ and the full version of SKQ (r=.992; p=.001). Conclusion The Mini-SKQ is a fast and easily administered questionnaire, adapted for screening semantic knowledge. The failure to the items of the mini-SKQ is highly correlated to AD. These first observations underline that mini-SKQ could potentially be attractive for screening semantic memory deterioration in a clinical use. [1] Laiacona M, Barbarotto R, Trivelli C, Capitani E. Dissociazoni semantiche intercategoriali descrizione di una batteria standardizzata e dati normativi. Archivio di Psicología, Neurología e Psichiatria, 1993 ; 54 : 209-48. [2] Simoes Loureiro, I., & Lefebvre, L. Le QCS : questionnaire de connaissances sémantiques pour déterminer le stade de détérioration sémantique chez les patients atteints de la maladie d’Alzheimer. Gériatrie et Psychologie Neuropsychiatrie Du Vieillissement, 2015 ; 13(2), 225–33.