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2017-04-03 - Article/Dans un journal avec peer-review - Anglais - 10 page(s)

Richard Vincent, Conotte Raphaël, Mayne David, Colet Jean-Marie , "Does the 1H-NMR Plasma Metabolome Reflect the Host-Tumor Interactions in Human Breast Cancer?" in Oncotarget, 8, 30, 49915-49930, doi: 10.18632/oncotarget.18307

  • Edition : Impact Journals, Albany (NY)
  • Codes CREF : Sciences biomédicales (DI3200)
  • Unités de recherche UMONS : Biologie humaine et Toxicologie (M125)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Centre de Recherche UMONS-Ambroise Paré (UMHAP)
Texte intégral :

Abstract(s) :

(Anglais) Breast cancer (BC) is the most common diagnosed cancer and the leading cause of cancer death in women worldwide. There is an obvious need for a better understanding of BC biology. Alterations in the serum metabolome of BC patients have been identified but their clinical significance remains elusive. We evaluated by 1H-Nuclear Magnetic Resonance (1H-NMR) spectroscopy, filtered plasma metabolome of 50 early (EBC) and 15 metastatic BC (MBC) patients. Using Principal Component Analysis, Partial Least-Squares Discriminant Analysis and Hierarchical Clustering we show that plasma levels of glucose, lactate, pyruvate, alanine, leucine, isoleucine, glutamate, glutamine, valine, lysine, glycine, threonine, tyrosine, phenylalanine, acetate, acetoacetate, β-hydroxy-butyrate, urea, creatine and creatinine are modulated across patients clusters. In particular lactate levels are inversely correlated with the tumor size in the EBC cohort (Pearson correlation r=-0.309; p=0.044). We suggest that, in BC patients, tumor cells could induce modulation of the whole patient’s metabolism even at early stages. If confirmed in a lager study these observations could be of clinical importance.