DI-UMONS : Dépôt institutionnel de l’université de Mons

Recherche transversale
Rechercher
(titres de publication, de périodique et noms de colloque inclus)
2008-04-01 - Article/Dans un journal avec peer-review - Anglais - page(s)

Gallo Dominique, Haddad Iman, Laurent Guy , Vinh Joëlle, Jacquemotte Françoise, Jacquot Yves, Leclercq Guy, "Regulatory function of the P295-T311 motif of the estrogen receptor a – does proteasomal degradation induce emergence of peptides implicated in estrogenic responses?" in Nuclear Receptor Signaling, 6, e007

  • Edition : Nuclear Receptor Signaling Atlas (NURSA), Houston (TX)
  • Codes CREF : Histologie (DI3212), Cancérologie (DI3349)
  • Unités de recherche UMONS : Histologie (M118)
Texte intégral :

Abstract(s) :

(Anglais) The way in which estrogen receptor alpha (ERalpha) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERalpha-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERalpha17p), we propose that ERalpha proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERalpha activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.

Identifiants :
  • PMID : 18432312
  • DOI : 10.1621/nrs.06007