DI-UMONS : Dépôt institutionnel de l’université de Mons

Recherche transversale
(titres de publication, de périodique et noms de colloque inclus)
2016-03-18 - Colloque/Présentation - poster - Anglais - 1 page(s)

Knoops Jérémie , Rubio Magnieto Jenifer , Clément Sébastien, Surin Mathieu , "DNA-conjugated polymer assemblies for biosensing : spectroscopy, modeling and application" in CHEMCYS, Blankenberge, Belgique, 2016

  • Codes CREF : Physico-chimie générale (DI1320)
  • Unités de recherche UMONS : Chimie des matériaux nouveaux (S817)
  • Instituts UMONS : Institut des Biosciences (Biosciences)
  • Centres UMONS : Centre d’Innovation et de Recherche en Matériaux Polymères (CIRMAP)

Abstract(s) :

(Anglais) Conjugated polyelectrolytes combine the optoelectronic properties of organic semiconductors and the physicochemical properties of polyelectrolytes, such as water solubility. They have proven effective for various potential applications, such as optoelectronic devices and the detection of biomolecules[1, 2]. In continuation of our previous studies [3, 4], we here report a study on self-assemblies formed by DNA and a conjugated polyelectrolyte, cationic polythiophene (CPT, see below), in aqueous solution. A combined approach involving (chir)optical spectroscopy and molecular modeling was used to get a better insight into the supramolecular organization of DNA/CPT assemblies. We show that their optical properties are dependent on the DNA sequence. Furthermore, we show that DNA/CPT assemblies can be used for DNA hybridization sensors, by detecting variations at the level of a single nucleotide. References 1. Liu, B. and G.C. Bazan, Conjugated Polyelectrolytes: Fundamentals and Applications. 2013: Wiley. 2. Jiang, H., et al., Angewandte Chemie International Edition, 2009. 48(24): p. 4300-4316. 3. Rubio-Magnieto, J., et al., Chemical Communications, 2013. 49(48): p. 5483-5485. 4. Rubio-Magnieto, J., et al., Soft Matter, 2015. 11(32): p. 6460-6471.