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2008-11-01 - Article/Dans un journal avec peer-review - Anglais - 9 page(s)

Shim Y.-H., Bougard F., Coulembier Olivier , Lazzaroni Roberto , Dubois Philippe , "Synthesis and characterization of original 2-(dimethylamino)ethyl methacrylate/poly(ethyleneglycol) star-copolymers" in European Polymer Journal, 44, 11, 3715-3723

  • Edition : Elsevier Science
  • Codes CREF : Chimie macromoléculaire (DI1315), Chimie quantique (DI1321), Catalyses hétérogène et homogène (DI1334), Optique (DI1250)
  • Unités de recherche UMONS : Matériaux Polymères et Composites (S816), Chimie des matériaux nouveaux (S817)
  • Instituts UMONS : Institut de Recherche en Science et Ingénierie des Matériaux (Matériaux)
Texte intégral :

Abstract(s) :

(Anglais) Novel synthetic transfection vectors with linear triblock and star-shaped diblock copolymer architectures have been synthesized by atom transfer radical polymerization (ATRP). Based on 2-(dimethylamino)ethyl methacrylate (DMAEMA) and copolymerization with poly(ethyleneglycol) a-methoxy, ?-methacrylate (MAPEG), the synthesis was realized using CuBr ligated with 1,1,4,7,10,10-hexamethyltriethylenetetramine (HMTETA) as catalytic complex and either ethyl 2-bromoisobutyrate (EBiB) or bis(a-bromoisobutyryl) N-methyl diethanolamine (DEA) or tris(a-bromoisobutyryl) triethanolamine (TEA) as (multifunctional)initiator. The polymers were characterized by GPC and NMR. The solution properties of these homopolymers and palm-tree-like copolymers were investigated by viscometry either in pure water or in buffered aqueous solutions. Interestingly, all the synthesized polymers show polyelectrolyte effect in Millipore water (25 °C) and in Hepes (20 mM) buffer solution (pH 7.4, NaCl 155 mM, 25 °C). Fitting of these viscometric data according to either Fuoss or Fedors equation allows for calculating the intrinsic viscosity of the polymers. These results are compared with dynamic light scattering (DLS) experiments to determine absolute masses. Finally, DEA based palm-tree-like copolymer is investigated to AFM measurement and micelles were observed at pH 8.

Notes :
  • (Anglais) Publié le 26 août 2008
  • (Anglais) Lecture en ligne: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TWW-4T9CCXT-9-R&_cdi=5573&_user=532054&_pii=S0014305708004151&_origin=search&_coverDate=11%2F30%2F2008&_sk=999559988&view=c&wchp=dGLzVlz-zSkWb&md5=9147ef20a601986b575ee598692967e6
Identifiants :
  • DOI : 10.1016/j.eurpolymj.2008.08.016