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2018-03-27 - Colloque/Présentation - poster - Anglais - 1 page(s)

Juszczak Florian , Vlassembrouck Maud, Tassin Alexandra , Legrand Alexandre , Caron Nathalie, Decleves Anne-Emilie , "Study of Renal Lipid Accumulation in Obesity-induced Chronic Kidney Disease in Mice. Benefits of an Endurance Exercise Training" in Mardi des Chercheurs (MdC2018), Valenciennes, France, 2018

  • Codes CREF : Néphrologie - urologie (DI3325), Physiologie générale (DI3220)
  • Unités de recherche UMONS : Biologie moléculaire (M122)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) Obesity is an independent predictor of chronic kidney disease (CKD). Previous studies demonstrated ectopic renal lipid accumulation in high-fat diet (HFD)-induced obesity in mice, leading to tubular cell structure impairments, inflammation and fibrosis. This work determines for the first time the effects of exercise training (ET) on renal lipotoxicity. A mouse model presenting HFD-induced CKD was used and the impact of ET was determined using a treadmill for ET protocol. Results suggest that ET leads to beneficial effects on obesity-related metabolic disorders as well as on renal function and kidney structure in HFD-fed mice.