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2008-01-01 - Article/Dans un journal avec peer-review - Anglais - 10 page(s)

Henoumont Céline , Henrotte Virginie, Laurent Sophie , Vander Elst Luce , Muller Robert , "Synthesis of a new gadolinium complex with a high affinity for human serum albumin and its manifold physicochemical characterization by proton relaxation rate analysis, NMR diffusometry and electrospray mass spectrometry" in Journal of Inorganic Biochemistry, 102, 4, 721-730

  • Edition : Elsevier Science, New York (NY)
  • Codes CREF : Résonance magnétique nucléaire (biophysique) (DI131B), Chimie de coordination (DI1319), Chimie organique (DI1313), Imagerie médicale, radiologie, tomographie (DI3243)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé), Institut des Biosciences (Biosciences)
Texte intégral :

Abstract(s) :

(Anglais) A novel gadolinium complex, derived from Gd-DTPA (DTPA: diethylenetriaminepentaacetic acid) and sulfaphenazole, intended to be a potential MRI contrast agent and to interact with human serum albumin (HSA), was synthesized and characterized. Its relaxometric properties were evaluated in water, and its binding to HSA was investigated by three techniques: proton relaxation rate analysis, NMR diffusometry, and electrospray mass spectrometry. The complex has a higher relaxivity than the parent compound (r(1) = 7.8 s(-1) mM(-1) at 310 K and 0.47 T and 7.7 s(-1) mM(-1) at 310 K and 1.41 T), a fast water exchange, and a very good stability versus zinc(II) transmetallation. All techniques agree with a high affinity of the complex for HSA, and competition experiments indicate that this contrast agent competes with ibuprofen for HSA. (c) 2007 Elsevier Inc. All rights reserved.

Identifiants :
  • DOI : 10.1016/j.jinorgbio.2007.10.017
  • PMID : 18096235