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2006-01-01 - Article/Dans un journal avec peer-review - Anglais - 12 page(s)

Saussez Sven , Kiss Robert, "Galectin-7" in Cellular and Molecular Life Sciences : CMLS, 63, 6

  • Edition : Birkhäuser, Basel (Switzerland)
  • Codes CREF : Histologie (DI3212), Cancérologie (DI3349)
  • Unités de recherche UMONS : Anatomie et Biologie cellulaire (M112)
Texte intégral :

Abstract(s) :

(Anglais) Galectins are a family of animal lectins with an affinity for ß-galactosides. They are differentially expressed by various tissues and appear to be functionally multivalent, exerting a wide range of biological activities both during development and in adult tissue. Galectin-7, a member of this family, contributes to different events associated with the differentiation and development of pluristratified epithelia. It is also associated with epithelial cell migration, which plays a crucial role in the re-epithelialization process of corneal or epidermal wounds. In addition, recent evidence indicates that galectin-7, designated as the product of the p53-induced gene 1 (PIG1), is a regulator of apoptosis through JNK activation and mitochondrial cytochrome c release. Defects in apoptosis constitute one of the major hallmarks of human cancers, and galectin-7 can act as either a positive or a negative regulatory factor in tumour development, depending on the histological type of the tumour.

Notes :
  • (Anglais) ISNN online 1420-9071
Identifiants :
  • DOI : 10.1007/s00018-005-5458-8
  • ISSN : 1420-682X