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2015-05-28 - Colloque/Présentation - poster - Anglais - 1 page(s)

Simoes Loureiro Isabelle , Lefebvre Laurent , "Highlighting the lexico-semantic deterioration in Alzheimer’s disease with a semantic knowledge questionnaire." in BAPS 2015-BAPS Annual Meeting, Vrije Universiteit Brussel, Faculty of Psychology and Educational Sciences, Belgique, 2015

  • Codes CREF : Neurosciences cognitives (DI4296), Sciences cognitives (DI4290), Psychologie cognitive (DI4211)
  • Unités de recherche UMONS : Psychologie cognitive et Neuropsychologie (P325)
  • Instituts UMONS : Institut de recherche en sciences et technologies du langage (Langage), Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Centre de Recherche UMONS-Ambroise Paré (UMHAP), Mind & Health (CREMH)
Texte intégral :

Abstract(s) :

(Anglais) Highlighting the lexico-semantic deterioration in Alzheimer’s disease with a semantic knowledge questionnaire Simoes Loureiro, Isabelle (1) & Lefebvre, Laurent (1) (1) Service de Psychologie Cognitive et Neuropsychologie, Institut des Sciences et Technologies de la Santé, UMONS, Mons, Belgium, isabelle.simoesloureiro@umons.ac.be In patients with Alzheimer’s disease (AD), lexico-semantic difficulties occur early and increase in the course of the illness. The bottom-up process theory is today well accepted: subordinate attributes tend to decline more rapidly than superordinate ones. Nevertheless, a specific issue in semantic memory investigation in AD is to determine the severity of the semantic impairment. Given that some authors doubt about the systematic apparition of semantic disorder in early AD (Chainay, 2005), we argue that the constitution of experimental AD groups must consider the semantic deterioration stage, as suggested by Hernandez et al. (2008). We thus propose a specific semantic knowledge questionnaire (SKQ), based on Laiacona et al.’s work (1993). SKQ consists of a multiple choice questionnaire with 30 items (15 living and 15 non-living items) associated with 4 questions (1. superordinate question, 2. intracategorial question, 3. perceptive question and 4. functional/thematic question). SKQ was proposed to 49 AD patients (44 females) and 33 healthy old people (18 females). Three experimental AD groups were created, based on the global cognitive deterioration: subjects with a MMSE score superior to 20 (N= 16 ; AD1); comprised between 16 and 19 (N = 12 ; AD2), or strictly inferior to 16 (N = 21 ; AD3). In a second analysis, we split our AD1 group in two subgroups based on SKQ score: AD1 with very mild semantic alteration (ADSD1) or with mild semantic deterioration (ADSD2). Groups were matched in terms of age and socio-cultural level. Anova on repeated measures show a significant group effect (F=32.313 ; α= .001), a significant question effect (D=72.447 ; α=.001) and a significant interaction effect (D=8.488 ; α=.001). Moreover, a significant correlation between the total errors at the SKQ and the MMSE score (r=-.737 ; α=.001) is observed. Finally, we show that ADSD1 and ADSD2 differ significantly on semantic scores while they don’t differ in global cognitive scores as measured by the MMSE. Our results suggest that our SKQ is adapted to highlight the semantic deterioration and the bottom-up process in AD: superordinate information are better preserved than subordinate information. We equally demonstrate that AD1 patients can show different semantic alteration, with mild or very mild semantic deterioration without any differences in global cognitive alteration. This result clearly show that research on semantic deterioration in early stage of AD must take into account the severity of the semantic alteration, while inter-individual differences can obviously occur.