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2007-03-01 - Article/Dans un journal avec peer-review - Anglais - 5 page(s)

Ris Laurence , Godaux Emile, "Synapse specificity of long-term potentiation breaks down with aging" in Learning & Memory (Cold Spring Harbor, N.Y.), 14, 3, 185-189

  • Edition : Cold Spring Harbor Laboratory Press, Cold Spring Harbor (NY)
  • Codes CREF : Neurophysiologie (DI3224)
  • Unités de recherche UMONS : Neurosciences (M119)
Texte intégral :

Abstract(s) :

(Anglais) Memory shows age-related decline. According to the current prevailing theoretical model, encoding of memories relies on modifications in the strength of the synapses connecting the different cells within a neuronal network. The selective increases in synaptic weight are thought to be biologically implemented by long-term potentiation (LTP). Here, we report that tetanic stimulation of afferent fibers in slices from 12-mo-old mice triggers an LTP not restricted to the activated synapses. This phenomenon, which can be anticipated to hinder memory encoding, is suppressed by blocking either L-type Ca++ channels or Ca++-induced Ca++ release, both well known to become disregulated with aging.

Identifiants :
  • ISSN : 1072-0502
  • DOI : 10.1101/lm.451507