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2017-12-20 - Article/Dans un journal avec peer-review - Français - 10 page(s)

Bashige V., Bakari A, Mbuyi-Kalonji S., Kahumba Byanga J., Duez Pierre , Lumbu Simbi J.-B., "Étude ethnobotanique, phytochimique et évaluation de l’activité antiplasmodiale de 13 plantes réputées antipaludéennes dans la commune du Kenya (Lubumbashi, RDC)" in Phytothérapie, http://dx.doi.org/10.1007/s10298-017-1152-x

  • Edition : Éditions Lavoisier (France)
  • Codes CREF : Chimie analytique (DI1314), Pharmacognosie (DI3410), Sciences pharmaceutiques (DI3400), Toxicologie pharmaceutique (DI3440)
  • Unités de recherche UMONS : Chimie thérapeutique et Pharmacognosie (M136)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
Texte intégral :

Abstract(s) :

(Anglais) ThisstudywascarriedoutinLubumbashibetween 2011 and 2013, and aimed to collect ethnobotanical knowledge about plants used as an antimalarial drug in the urban community of Kenya, to evaluate their antiplasmodial activity, and to determine their chemical composition. Ethnobotanical data were collected based on free interviews using a questionnaire. The antiplasmodial activity was evaluated by the Rieckmann microtest method while chemical screening was carried out using the classical solution reactions. From 13 traditional healers (average age: 51.5 years, extremes: 28–76 years), 13 plants species derived from 8 families dominated by Fabaceae (46.2%) and grouped into 13 genera was collected. The leaf is the most common part used (53.8%) prepared preferentially as a decoction (85%) and administered orally (65%). Methanolic extracts of the leaves ofLandolphiakirkiishowedthemostpromisingantiplasmodial activity (IC50: 9.9 μg/ml). Alkaloids, flavonoids, quinones, terpenoids, steroids, and saponins have been identified. Traditional health practitioners in Kenya Commune therefore have and use antimalarial herbal recipes that contain several metabolites and have proven to be effective.