DI-UMONS : Dépôt institutionnel de l’université de Mons

Recherche transversale
(titres de publication, de périodique et noms de colloque inclus)
2007-01-01 - Article/Dans un journal avec peer-review - Anglais - 4 page(s)

Yu G., Yamashita M., Aoshima K., Takahashi M., Oshikawa T., Takayanagi H., Laurent Sophie , Burtea Carmen , Vander Elst Luce , Muller Robert , "A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography?" in Bioorganic & Medicinal Chemistry Letters, 17, 8, 2246-2249

  • Edition : Elsevier Science, Oxford (United Kingdom)
  • Codes CREF : Résonance magnétique nucléaire (biophysique) (DI131B), Sciences biomédicales (DI3200), Pharmacocinétique (DI3431), Chimie organique (DI1313), Imagerie médicale, radiologie, tomographie (DI3243)
  • Unités de recherche UMONS : Chimie générale, organique et biomédicale (M108)
Texte intégral :

Abstract(s) :

(Anglais) A new low-molecular weight dendrimer-like M RI contrast agent (Gd-D1) has been synthesized and characterized in vitro by proton and oxygen-17 relaxometry. Its pharmacokinetic parameters and biodistribution patterns were evaluated on rats. Its in vitro and in vivo properties, that is, the longitudinal relaxivity (defined as the increase of the water proton longitudinal relaxation rate induced by one millimole per liter of Gd-D1) equal to 5.6 s(-1) mM(-1) at 20 MHz and 310 K, the elimination half-time equal to 85 min, and its low accumulation in liver and spleen, underline its potential as a blood-pool MRI contrast agent.

Identifiants :
  • DOI : 10.1016/j.bmcl.2007.01.067
  • ISSN : 0960-894X

Mots-clés :
  • (Anglais) magnetic resonance imaging
  • (Anglais) pharmacokinetics
  • (Anglais) MRI contrast agents