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2007-03-12 - Article/Dans un journal avec peer-review - Anglais - 9 page(s)

Yancheva Elena, Paneva Dilyana, Maximova V., Mespouille Laetitia , Dubois Philippe , Manolova Nevena, Rashkov Iliya, "Polyelectrolyte complexes between (crosslinked) N-carboxyethylchitosan and (quaternized) poly[2-dimethylamino)ethyl methacrylate: preparation, characterization and antibacterial properties" in Biomacromolecules, 8, 3, 976-984

  • Edition : American Chemical Society, Washington (DC)
  • Codes CREF : Chimie macromoléculaire (DI1315), Catalyses hétérogène et homogène (DI1334)
  • Unités de recherche UMONS : Matériaux Polymères et Composites (S816)
  • Instituts UMONS : Institut de Recherche en Science et Ingénierie des Matériaux (Matériaux)
Texte intégral :

Abstract(s) :

(Anglais) Novel polyelectrolyte complexes (PECs) between N-carboxyethylchitosan (CECh) and well-defined (quaternized) poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) have been obtained. The modification of chitosan into CECh allows the preparation of PECs in a pH range in which chitosan cannot form complexes. The CECh/PDMAEMA complex is formed in a narrow pH range around 7. The quaternization of the tertiary amino groups of PDMAEMA enables complex formation with CECh both in neutral and in alkaline medium. Cross-linked CECh is also capable of forming complexes with (quaternized) PDMAEMA. The antibacterial activity of (cross-linked) CECh, (quaternized) PDMAEMA, and their complexes against Escherichia coli has been evaluated. In contrast to (quaternized) PDMAEMA, (cross-linked) CECh exhibits no antibacterial activity. The complex formation between cross-linked CECh and (quaternized) PDMAEMA results in a loss of the inherent antibacterial activity of the latter in neutral medium. In acidic medium, the complexes exhibit strong antibacterial activity due to complex disintegration and release of (quaternized) PDMAEMA.

Notes :
  • (Anglais) Publié en ligne le 22 février 2007
Identifiants :
  • DOI : 10.1021/bm061029j