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2017-05-18 - Colloque/Présentation - poster - Anglais - 1 page(s)

Seminerio Imelda , Kindt Nadège , Descamps Géraldine, Bellier Justine, Lechien Jérome , Mat Quentin, Pottier Charles, Delvenne Philippe, Journe Fabrice , Saussez Sven , "Stromal FoxP3-positive T Cell Number Combined to Tumor Stage Improves Prognosis in Head and Neck Squamous Cell Carcinoma" in BIT's 10th Annual World Cancer Congress 2017, Barcelona, Espagne, 2017

  • Codes CREF : Histologie (DI3212), Sciences biomédicales (DI3200), Immunologie (DI3213), Oto-rhino-laryngologie (DI3342), Cancérologie (DI3349), Biologie cellulaire (DI311D)
  • Unités de recherche UMONS : Anatomie et Biologie cellulaire (M112)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)

Abstract(s) :

(Anglais) Head and neck squamous cell carcinomas (HNSCCs) represent the sixth most common cancer worldwide, with about 550.000 new cases diagnosed each year. In addition to tobacco and alcohol abuse, infection with human papillomavirus (HPV) has also been demonstrated as a new risk factor of these cancers. Some studies have investigated the role of host immune response in HNSCCs progression and regulatory T lymphocytes (Treg) may play a role in the development of these cancers. In this study, we evaluated FoxP3-positive T cells number in HNSCCs and we reported its prognostic power in comparison to other risk factors. We showed that FoxP3+ T cell infiltration increases with tumor progression from normal epithelia, dysplasia to carcinoma and that this increase is higher in HPV-positive/p16-positive patients, than in negative ones. Furthermore, in vivo experiments conducted on C3H/Hen mice revealed that HPV16-E7 oncoprotein is associated with an increased FoxP3 T cell recruitment in tumor, a delay in tumor onset and an improved animal survival. In addition, mutivariate Cox regression analyses demonstrated that high FoxP3 T cell number in stromal compartment is associated with longer patient recurrence-free survival and overall survival. Finally, FoxP3 T cell number increases the prognostic value of tumor stage.