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2015-01-01 - Article/Dans un journal avec peer-review - Anglais - 13 page(s)

Decleves Anne-Emilie , "Obesity and kidney disease: differential effects of obesity on adipose tissue and kidney inflammation and fibrosis." in Current Opinion in Nephrology & Hypertension, 24, 1, 28-36, doi: 10.1097/MNH.0000000000000087

  • Edition : Lippincott Williams & Wilkins, London (United Kingdom)
  • Codes CREF : Néphrologie - urologie (DI3325), Diabétologie (DI3373), Lipides, steroides, membranes (DI311C)
  • Unités de recherche UMONS : Biologie moléculaire (M122)
  • Instituts UMONS : Institut des Sciences et Technologies de la Santé (Santé)
  • Centres UMONS : Mind & Health (CREMH)
Texte intégral :

Abstract(s) :

(Anglais) PURPOSE OF REVIEW: To provide a perspective by investigating the potential cross-talk between the adipose tissue and the kidney during obesity. RECENT FINDINGS: It is well established that excessive caloric intake contributes to organ injury. The associated increased adiposity initiates a cascade of cellular events that leads to progressive obesity-associated diseases such as kidney disease. Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. In parallel, proinflammatory processes within the adipose tissue can also lead to pathophysiological changes in the kidney during the obese state. SUMMARY: Despite considerable efforts to better characterize the pathophysiology of obesity-related metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies focused on regulating adipose function with respect to AMP-activated protein kinase activation, NADPH oxidase function, and TGF-β may contribute to reducing adipose inflammation that may also provide renoprotection.